Ok. This is a cleaned up version of a drawing that I just tested. The  tabloid size sheet was quick to Preview, but generating the PDF took several minutes, and the Activity Monitor indicated that it is Autocad that is "not responding"

The Printer that it's set up for is an HP, but as I said, I never print straight to the printer. I always make a PDF first. It's more predictable that way. That said, if there's a better way to do it, I'd love to hear it! I don't use anything other than the "Save to PDF" option that is native to the OS.

Thanks so much

Jessie