@ZTR88 , 

Thank you for that extra troubleshooting! Where the issue is not happening in 2018, but is in the two later versions it could definitely be an unexpected reaction from the program. it's still odd that profiles effect it though. Were you testing with the same profiles in 2018 and 2020? Also were you able to test creating the new profile? 

In order to confirm and escalate to our team, I will need a copy of the database we can reproduce the issue from. Are you able to share this? I can send a private upload link if you like, or you can use the same one from my earlier post.