I've made a screencast of operating conditions with 3D Acceleration On and Off. About the 1:30 mark is where the DWG in question is loading and lagging. The jerking movements of the screen are actually me trying to be smooth and controlled with mouse panning. 

About the 5 min mark I load a fairly more complex model in ESTmep and the operation is fluid, responsive and seems to handle without any hiccups. 

Screencast

I don't know if I inserted the screencast correctly so up there is a direct link

3D Acceleration toggle showed little to no difference from what I could tell