I understand the images but I'm not quite sure what you're asking for help with.
Do you need help with design line functionality?
Or the best way to create a sloped line?
Or the best way to insert different fittings?
Here is my response based on what I think you're after:
Draw a 3d polyline from start to end point (with no slope). Start a new design line. Trace the 3d poly with correct pipe size. Insert quarter bend node at the top 90 looking down. Go to the drainage tool for design line. Set the source to the low point, set the slope to 96. Now the top node will be higher that needed. Select top two points and drop down to meet existing POC. fill in 3d. done.
Might be an easier way but I never have any luck with fixing points in design line. See attached screencast/video for my example.
Stuff in red is your existing stuff.
If the video isn't what you were after, please reply and I'll see what I can do to help!