Just to clarify, you all are talking about two different sets of commands that often get confused. Wfberry is referring to LAYISO and LAYUNISO, but arpenteur is asking about the object isolation commands (nothing to do with what layer they're on), which most users I talk to haven't yet noticed.
HIDEOBJECTS temporarily turns off the display of selected objects, ISOLATEOBJECTS temporarily turns off display of all objects not in the selection set, and UNHIDE or UNISOLATEOBJECTS restores display of previously hidden objects. The hide effect is ignored by plotting (hidden objects remain hidden but are still plotted as they would be otherwise), and it's not saved when the drawing is closed.
LAYISO temporarily creates a layer state to store the current configuration, and then turns off or vpfreezes all layers except those of the selected object(s), and LAYUNISO restores the previous layer state.
I love the HIDEOBJECTS command for getting a large TIN surface or aerial out of the way for some quick drafting and not having to remember to turn it back on before I plot.