You may have already done some of this however excuse my ignorance and let me explain how to fix the issue.
I have had to figure out this issue in both LT and Arch Desktop.
If you are using architectural desktop, make sure that your Z axis cut line is set along the plane that you would like printed.
Take the existing drawing that you are working in, turn on and unlock all the layers. Get rid of any garbage and unwanted blocks and lines that are not needed.. Use Zoom Extents to make sure that you got everything. If there are too many unwanted lines inside of your drawing, Use select similar and or Isolate them to remove. Once you get it cleaned up the best you can, Purge. After this, select all and use the flatten command to return everything to the Z-(0)zero coordinance.
Start a fresh drawing from scratch and copy the existing project from a reference point. I typically use the bottom left hand corner of the structure. Copy your work and paste it as a block(ctrl+shift+V) into the scratch drawing at 0,0,0 coordinance.
Hatch is generated using coordinance and can get tweaked out if you are a mile outside of home...
Make sure that the block of your work is pasted to the 0,0,0 location per the base point that you chose and explode it. Now purge the drawing again just to be sure that all is good.
Use the Dview command. Set it to 0,0,0 and set the camera to 0,0,1. Doing this will make certain and eliminate other steps that would otherwise have to be noted.
Create your layout tab and set up your title sheet with a viewport, again purging after doing so. Lock your viewport at the correct scale and make sure that the PSltscale is set to zero. Refreshing inside the viewport will confirm that this is correct and your linetypes are correct. go back into paperspace and zoom extents.
Right click on your now proper layout tab and go to settings. Make sure that your .CTB, plot style is set per your standard. Check the boxes "plot with transparencies", "Plot paperspace last" Set quality to "Normal" and make sure that unless you are printing at other than 100% the "Scale Lineweights" box is unchecked.
Make sure that the printer is set to "DWG to PDF" and your sheet size is correct for the media that you intend to print, select apply and close.
Pick on the Autocad tab at the top left of the screen. The Red "A". Pick on "Export" and export the .pdf to a folder of choice. Open and preview the drawing.
If it is still still wonky, make sure that your Postscript settings are turned off. Make sure that your .ctb is configured in a standard that has not been changed by accident or by someone else if it is on a server or shared. Double check your print settings and make sure that you have the most current updates from autodesk and adobe. Make sure that your line-types are set to Bylayer and not overridden or "By-Block"
If you are printing remotely or using a wifi signal, it could be compressing the file and removing data to save space. I have encountered this and it does happen.
These steps should fix your issue. If you are still having issues, feel free to comment and I will fix. There are other xref involvements and transparency-screening factors that may be an issue.
A good general rule is to always take into consideration your coordinance in both model and paperspace. Keep your drawing clean without any cancer and merge any multiple line-types that are assigned to do the same thing. I have opened drawings with 20+ wall type layers A-Wall, A-Wall-Elevation, A-Structure-Wall, A-Wall-Envelope, etc.. I understand the theory of AIA standardization however it gives other users too much freedom and creates chaos. A good way I have found to keep things simple is to use layer names that make sense like "Wall", "Window", "Cabinetry", "Dim-48" etc... and assign a neutral color like red, yellow, cyan, magenta, blue, to each. Simple is good and it saves time. Time is money.
Good luck and cheers.
-Bostick