This question comes up from time to time... you want to have wire numbering automatically come in with wire color, gauge, and/or type information encoded right into the wire number itself. You don't want wire numbers like "123" and "124"... you really want "123-RD-14" and "124-BLK-10".
You can do it ! Use AcadE's wire numbering "Wire Layer/Format Overrides" feature. Drill down to the setup dialog:
AcadE 2004/2005 - go to the Project dialog --> Miscellaneous Settings --> Wire Numbers --> Toggle ON - Use Wire Layer/Format overrides --> Setup
AcadE 2006 - right-click on project name in the project list Enhanced Secondary Window --> Properties --> Wire Numbers --> Toggle ON - Use Wire Layer/Format overrides --> Setup
You're now on the "Assign Wire Numbering Formats by Wire Layer" subdialog. This is where you will enter each wire layer name (wild cards OK) and the wire number format that you want to see for wire numbers on that wire layer.
For example, let's say you routinely use wire layers "RED_14_THHN" and "BLK_10_XHHN" in drawings in your project. Whenever you have a wire number on the red wire, you want AcadE to automatically append a "-RD-14" suffix to the wire number. For wire numbers generated on wires drawn on layer BLK_10_XHHN you want AcadE to automatically go with wire number plus a trailing "-BLK-10".
So here's what you do. On this subdialog you enter in RED_14_THHN in the "Wire layer name" box. You enter %N-RD-14 in the "Wire number format for layer" edit box. Then hit Add.
Next enter BLK_10_XHHN in the "Wire layer name" box and %N-BLK-10 in the "Wire number format for layer" edit box. Hit Add again. Keep going until you have all possible wire layers set up. This info is stored right in the project's ".wdp" file (entry +[22]) and is applied across all drawings listed in your project.
Now, when you run AcadE's Auto Wire Numbers command on any drawing in your project, non-fixed wire numbers should update if they are associated with wires that are tagged in your override list.