ITEM is the attribute that holds a symbol's item number assignment. It controls nothing. It is a result of how you've assigned item numbers across the project.
You don't have to fill in the item attribute manually, so long as ACADE has a format of item sequencing that fits in with your standards. (See Trond's post)
However, if you are using a system whereby the item numbers are assigned before you do any drawings, you may end up with problems. Seriously, your best bet there would be to change things so that you can accept the way ACADE does it automatically. These options can be seen under Project Properties, in the 'components' tab. If you are faced with item numbers that are assigned before you ever start to draw, then I'm fairly certain that you won't be able to avoid having to type each one in each and every time.
Generally the workflow is to draw the schematic, draw the footprint layouts, and then run the item resequence command so that the item numbers get assigned. Using the ACADE workflows result in item numbers that can be updated (depending on your version) even after adding new components to the project.
Hope this helps,
Jim

Jim Seefeldt
Electrical Engineering Technician