In the IIS Manager, first click on "Application Pools" and make sure the default pool is set to .NET 4.0, Classic Mode. See attached "iis-0.png".
Then click on the toplevel node on the left (your machine hostname) and double-click on "ISAPI and CGI Restrictions". See attached "iis-1.png".
Make sure ASP.NET is set to "Allowed". See attached "iis-2.png".
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