Sorry - Edit and Continue definitely does not work debugging 64bit applications on 64bit Windows. This is a general issue with Visual studio, that is not related to AutoCAD itself.
It's totally possible to make AutoCAD 32bit run in Windows 64bit, but we don't support it. Technically speaking I don't see any reason why it wouldn't work as normal - yes, it would certainly solve your edit and continue issue in the debugger. As I have said before, if it solves an issue for you, then go for it.
FYI - We don't support 32bit AutoCAD on 64bit Windows because their is a huge effort testing each platform configuration. Because we already have a 64bit version of AutoCAD that runs on 64bit Windows it doesn't make business sense for us to test and QA a scenario that is most likely < 0.01% of our business.
I'm glad that's been said out-loud as there were a few missleading posts that implied that is was possible.
I don't know if i got the wrong end of the stick when reading them but it implied I thought that hitting breakpoints on a 64 bit machine was possible. It was over a year ago. I can't find them right now but can have a search later if needs be?
Actually, not hitting break points is different topic to this one, but i will say that it's similar in a way because it also occurs while debugging AutoCAD 64bit. The problem is that AutoCAD uses a stack swapping technology called 'Fibers' (Fibers are a deprecated technology from Microsoft which we are working on removing) and fibers do not work well with .NET, and in turn mess up Visual Studio break points on 64bit.
The quickest solution is to set NEXTFIBERWORLD=1, however, the downside with that setting is that multiple document commands will stop working, as will posting commands from the Ribbon.
Is someone from Microsoft watching? I got this e-mail litteraly 5 mins ago:
Edit and continue now available for 64 bit. :d.
(Fibers are a deprecated technology from Microsoft which we are working on removing)
Many tx for all the information.
Sorry but I didn't read anything that I wanted to run with, however, further investigation using some of the keywords on this thread unearthed a 'longbow' solution which has now solved my problem. I am now running 32bit 2010, 2013 and 2014 on my 64bit machine (no 64bit versions of AutoCAD at all), with Edit and Continue working fine, and I'm back up and working as before.