Hello,
my Inventor installation started suddenly crashing on launch.
I tried to reinstall it several times (full clean uninstall performed before, windows and drivers updates made), having had some corrupted files issues last week. However the problem didn't come from there.
I noticed that in the error message the faulty file was the clr.dll file of the .net framework. My version was 4.0 and up to date, as it is requested in the IV requirements. However I tried to install .NET 4.5 to see if it would help, and indeed it worked.
I can't remember exactly, but I might have installed IV SP1 or 1.1 only last week which might have caused this issue or maybe an update to the .NET framework. Sorry I cannot pinpoint exactly what caused this issue, but installing .NET 4.5 solved it.