For many customers, who have contacted Autodesk Product Support through their Subscription accounts, the -21 license error has resolved it’s self before anyone can react about it. I’d first off recommend a reboot.
Other users who have received this error have resolved it by starting and activating AutoCAD as an administrator, often using the “As Administrator” option when right clicking the startup icon. After it was activated it worked for the “Users” and “Power Users.”
If neither of these works you might try backing up, deleting these files, and then starting AutoCAD again:
Windows 7/Vistal
C:\ProgramData\Autodesk\ADLM\CascadeInfo.cas
C:\ProgramData\Autodesk\ADLM\ ProductInformation.pit
Windows XP
C:\Documents and Settings\All Users\Application Data\Autodesk\ADLM\CascadeInfo.cas
C:\Documents and Settings\All Users\Application Data\Autodesk\ADLM\ProductInformation.pit
Also try forcing reactivation by deleting the trusted storage files for the license manager. When starting and reactivating the license system will rebuild these.
Windows 7/Vista
C:\ProgramData\FLEXnet\adskflex_00691b00_tsf.data
C:\ProgramData\FLEXnet\adskflex_00691b00_tsf.data_backup.001
XP
C:\Documents and Settings\All Users\Application Data\FLEXnet\adskflex_00691b00_tsf.data
C:\Documents and Settings\All Users\Application Data\FLEXnet\adskflex_00691b00_tsf.data_backup.001
Douglas Lauritsen, Autodesk Product Support
Douglas Lauritsen
Support Specialist
Product Support
Autodesk, Inc.