I know this one is older than the hills but I just ran into an issue with corrupted MapGuide Studio 2010 "map" files. This is going to be strange, but do read on. We have an issue while loading ESRI's ArcGIS. For some reason windows insists that when ArcGIS is loaded it needs to reload AutoCAD Map 3D and starts looking for the disk. The supposed workaround is to rename the "Geospatial Coordinate Systems" folder, found in C:\Documents and Settings\All Users\Application Data\Autodesk\, to "Geospatial Coordinate Systems Temp". I did this today in an attempt to solve the constant reloading issue and found, a while after I had done that, that one of my MapGuide Studio map file was corrupted. Unfortunately I did not put 2 and 2 together and tried, upon the suggestion of some posts, to recreate the Mapguide Studio map. Of course this failed and every time I saved the darn thing, it corrupted again plus MapGuide Studio kept on crashing. To make a long story short I finally figured out that the source of the problem had something to do with the map file's coordinate system settings at which point I did make the connection and renamed the directory back to what it should be. After that all was well again.
As a developer I find it strange that renaming a folder would not cause some meaningful error like "Hey, I can't find this folder, what's up with that!" Instead it throws a project into complete mayhem. Looks like someone wasn't doing their homework when it comes to error trapping. Tisk, Tisk