I use a Logitech mouse, the performance MX, they have a mouse configuration program, "setpoint" where the scroll wheel direction and speed and a whole lot more can be set. Your mouse might be different but try poking around and see if you have a way to configure your mouse. It's not inside Autocad its part of the mouse software.
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Thanks for the input. I would suspect though that the OP may have a new computer and mouse and therefore this issue was resolved with hardware.
They do not seem to have come back to the thread in four years.