Grab a freebie called REVO UNINSTALLER, use it's most aggressive setting to
remove your old version of ADR and any signs of the new one. Also get and
use a Windows Registry Cleaner (if you have other Autodesk products, be
prepared to reinstall them).
Restart Windows, try a new install.
"0x643: Internal Error" is a Windows system problem related to the Registry
from what I understand.
I can confirm that Design Review 2010 doesn't install with Vista Business x64 with Inventor Suite 2009 installed. Downloaded the installer from http://www.autodesk.com/designreview-download and at first VB 2008 C++ runtime failed with 0x642 internal error. A manual download and install of VB 2008 C++ runtime resolved that error but now install fails with Design Review 2010 0x642 internal error. Removed True View 2009 and Design Review 2009 from Windows Add/Remove Programs and the error persists. Had to give up and reinstall Design Review 2009 from http://download.autodesk.com/esd/designreview/SetupDesignReview2009.exe just to get back to work. Very disappointing.
Thanks guok for your help, but it turns out I had a different problem. I uninstalled ADR 2009 and the mentioned folders were not present. I again tried to install ADR 2010 using the online installer (from http://usa.autodesk.com/adsk/servlet/pc/index?id=12423405&siteID=123112). That again failed with 0x642 for the visual basic runtimes (which i manually installed). I then downloaded the offline installer (from http://usa.autodesk.com/adsk/servlet/pc/item?siteID=123112&id=10336080) and it told me the visual basic runtimes were missing (but I manually installed..?). After re-reading the help (from http://download.autodesk.com/esd/designreview/2010/ADR_Install_Guide.htm) it mentioned downloading the vb runtimes and provided links to microsoft's website for the x86 versions. I assumed that i needed the x64 versions for my 64-bit computer but after installing the x86 versions, the offline installer worked fine.
So I guess using x86 vb-runtimes and using the offline installer works. (Haven't tried the online installer with x86 vb-runtimes pre-installed, but I'm guessing maybe the online installer is trying to install the x64 versions? and results in the 0x642 error? (just a guess)).