I usually datareference the ailgnments so that is easy enough to do twice.
I usually do my profile work in a file that I xreference in.
if there is enough room on the sheet, you can have both alignments showing and stationed. then show both profile views in separate viewports below and you are done.
I set my sheets up manually because I find it is easy enough to do and many times my workflow is not linear. A sheet set needed today is not always the one I need the next day or the day after.
I'm using the sheet set manager followed by "Create View Frames". This is my first time creating plan and profile sheets. I data reference both of the alignments and profiles.