rhschneider, please make your Subject line a bit more specific next time. It's always good to include your version in the message, but the subject needs to mention what you are asking about.
Also, there's a search box you can use in the upper right side of the forum window. Entering "cannot save" into that box gives a number of different solutions, including a hard drive being full, audit, purge, among others. Have you tried any of these suggestions?
Have ver 1.108.0.4 SP1
Only have problem when using River Module. Notice River is a bit quirky. Has any discussions developed yet?