Just a thought...
Civil 3D writes an instance of the image to your local TEMP directory. I have noticed serious performance issues with a cluttered temp directory.
It does this when using the Autodesk FDO for Provider for Raster, however my regens are not unreasonable when inserting raster images in this manner.
When I attach images in the reference manager or using Raster Design I am not aware of local instances saved to temporary directories.
To be sure I have created new temporary directories for Civil 3D to use but the problem persists when images are attached in the reference manager.
AutoCAD wont even load long enough to load the WSCOMMCNTR2 or maybe that is the problem it doesnt load the WSCOMMCNTR2???
Just did a fresh install per Autodesk instructions and still not responding after it starts to load. never gets to the splash screen.
...and this is another thing that occurs all too frequently... and inevitably causes a lot of rework
For me if I not disable but totally exit out of Norton my issues go away. I believe Norton is stopping some of the processes in C3D. C3D would start to "not respond" for many things that seemed unconnected but when I shut off Norton it fixed the issues.
Civil 3D 2011 SP1
Win 7 Pro x64
ATI Firepro 4800
We're using Nortons Hosted Endpoint Protection and we don't have the long hangs like you guys are discussing.
I am experiencing a problem with my graphics card locking up my OS and have to hard reboot, but that seems to happen in other graphics heavy applications IE Google earth.
As for the not responding messages, those only pop-up because you're clicking on and off the program when it's still processing and doesn't not actually mean that autocad has locked up.
It has become my routine to disable norton for 5 hours at a time.
once the problem starts you must exit acad to stop it. (and possible reboot??)
Disabling norton after the first occurance will not stop it
Had a similar problem with AutoCAD and Inventor 2011. Go to the control panel, add/delete programs, and click on the .NET framework. When it asked to remove or repair simply click on repair. This will fix it.