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As far as I know, there is no way to loft profiles/sections that are contained within a blocks. If you need to keep the sections, perhaps use COPYTOLAYER to copy the blocks to another layer where you can explode and loft them.
With regard to lofting with a hole, it is possible if the profile/section is a single object that defines both the perimeter and the void, such as a REGION, otherwise probably not.