Most likely yes (Python supports COM as far as I can see from google).
I tried to import robotOM library with Python, but it looks like the library file as to be a .py file, not a .dll file. Does such a file already exist ? If not, how can I convert the Interop.RobotOM.dll file to a .py file ?
I found the syntax to import and use the API with Python :
import clr
clr.AddReferenceToFileAndPath("C:\...\Interop.RobotOM.dll")
import RobotOM as rbt
Then you can call RSA classes as follow :
Robot = rbt.RobotApplication
etc...
It may be usefull for Grasshopper users...