Our office has definitely noticed the same thing. 2010 is very "moody". You can be mid command and poof! The whole thing goes away. No warning. For no apparent reason. Fatal Error messages are much more common with this version as well. My favorite is when it "can generate this view, view will be closed" comes up. This is the signal that you not only can't work any more, but you can't save any more either. Your only option is to crash our without saving, leaving your local file useless since it then becomes incompatible with the Central file. We too have updated and believe it's a memory issue. Personally, I've started restarting my machine multiple times a day, in an effort to periodically free up some memory, but it doesn't seem to help.
What is going on?