FR should run fine on IIS 6. My guess is that the permissions for your IIS client may be out of sync.
A couple of things to check just to make sure everything is working fine:
1. The System ODBC connection should be set up for the database (Access = back end database, SQL & Oracle = Middleware Access database) using the Microsoft Access Driver.
2. The conifigure.xml file should be pointing to the proper database via that same ODBC connection name.
3. The folder containing the Access database and the database itself should have Sharing and Security open to the IIS user (Internet User Guest Account).
4. The IIS folder (this is the Facility Request location) should be shared and open to security for the Internet User Guest Account.
You'll also just want to check the settings in IIS for the default page. You may also notice that based upon your IP settings, some folks need to use the default IP address (rather than the http://localhost/FacilityRequest/Default.asp setting). So, your best bet is to open Facility Request in IIS, go to the Default.asp file and right click to open it in a browser. Your IIS should resolve what works best for your system.
If you can get this approach to work, then you can start locking down some of the permissions, etc as you see fit.
Hope that helps,
Jon Luby