Is this the best way to model the material shown in the datasheet?
It should be sufficient. If you have problems guessing the viscosity values from the datasheet points it may be helpful to use an automatic tool for this like this one. I'd double-check if the result strain rate is within the available data range. If not Simulation CFD will not extrapolate the values but instead use the nearest value from the table.
Is there a difference between Shear Rate and Strain Rate?
Not for this software.
Are there other variables that would contribute to this gross error in pressure drop?
Apart from the general ones like mesh and number of iterations (convergence), it may be helpful to try out the advection scheme ADV 4 that is designed for flows in long narrow pipes (if this is the case).
Do you specify a flow rate at the inlet?
It may be also helpful to move the inlet/outlet-faces away from regions of high gradients, to allow the flow to develop (inlet) and calm down (outlet).
Is the flow laminar or turbulent? If the latter it may be necessary to use the Low Re type of the kEpsilon turbulence model, since the boundary layer may be relativly thick. If this is the case (kEpsilon turbulence model not appropriate due to a thick boundary layer in relation to the mesh), it is usual that the pressure drop is under-predicted. See the corresponding help topic ( > Wall Model) for more information on this.

Marco Müller
Product Support Specialist
Digital Simulation
Autodesk, Inc.