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I set my hatch transparencies to 75%. I saved and closed the drawing. When I reopened the drawing the transparency values were all at 0.
Do you see this problem while setting the value for any drawing. If so, can you try resetting your AutoCAD profile as per the steps below,
http://usa.autodesk.com/adsk/servlet/ps/dl/item?siteID=123112&id=14823324&linkID=9240617
Also try to enable hardware acceleration and see whether it helps.
http://usa.autodesk.com/adsk/servlet/ps/dl/item?siteID=123112&id=5554010&linkID=9240617
If not, What type of hatches are using in your drawing ? Can you able to send one to us to investigate further.