Always draw one to one if it is a drawing entity (gear, steel shape ... etc). If it is just a symbol (revision flag, whatever) make it the size you want it to be printed. If you dim in MS you may want to make it annotative.
For our application, I personally only draw parts and assemblies in MS (@ 1:1) and dim in PS, therefore my symbols are all created the size I want at print time.
OOTB Blocks are all ready drawn at 1:1
Therefore your new blocks should be drawn 1:1 or at the same size as the OOTB Blocks as DJ stated.
(of course it is hard to draw a 65' tractor trailer on a 20" monitor at 1:1. A lot of panning around. )
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