You didn't say which version you are using, but I believe 2007 came with the 'publish' option. You can find this in the 'File" drop down menu.
You can add all the layouts you want from the same drawing or select several different drawings, both the model space and all the layouts you've developed in each drawing file.
In the second column is the 'Page Setup / 3D DWF' label. From here, you can import the page layout setup from any drawing you'd like and if you select all the files listed there, you can change it for all of them.
You can also create and specify different page setups for different layouts if you have the need to do so.
I hope this helps!