The first ACAD.pgp file found on the AutoCAD search path should get loaded automatically. If you make changes during a drawing session that you would like implemented, the REINIT command will call up a dialog that will allow you to reinitialize the PGP file.
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David Koch
Autodesk Discussion Group Facilitator
Using ADT 2004 at work; access to 2005, 2006, 2007 & 2008 at home