If you happen to be using Windows 7, try right-clicking AutoCAD Mechanical 2012 and choosing "Run as administrator" to launch it. It might also be good to try turning off User Account Control:
If the above doesn't help, then try resetting AutoCAD to defaults by clicking Start > All Programs > Autodesk > AutoCAD Mechanical 2012 > Reset Settings To Default.
Let me know if this helps.
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Go ahead and try resetting AutoCAD Mechanical to defaults. If that doesn't fix the error, then do a repair or uninstall/reinstall of AutoCAD Mechanical 2012.
Could the error be coming from your template file? Try designating a different DWT file in the same location as the default template that you want to use.
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