Is it really so that multileaders cannot be aligned to layout like annotative Mtext? When my technician told me "it's not working", I started to look at it. Spending half a day reading help and googling around I feel like dropped from the moon.
How can I force my leaders to match layout orientation? Using AutoCAD 2011
create a new user coordinate system in the viewport. click inside the viewport to get into modelspace, type ucs, n (for new), v (for view) and enter. If you so desire, you can type ucs again and the s (for save) and give the new ucs a unique name.
Since I usually have only one layout per drawing I use UCS View option. It is easy to change back to UCS World when I am done with text, dims, and mleaders if necessary. I find it saves the step of creating and using a named UCS. If I had multiple layouts in a drawing all using the same alignment then I would use a named UCS.